Resposta Imune Contra O SARS-CoV-2

Authors

  • Laís Lima de OLIVEIRA
  • Amélia Maria Ribeiro de JESUS
  • Roque Pacheco de ALMEIDA
  • Ricardo L. Louzada da SILVA L. Louzada da SILVA

Abstract


Coronaviruses (CoVs) are a large subfamily of enveloped, single positive-strand RNA viruses. The first case of SARS-CoV-2 infection was identified in December 2019, after sequencing clinical samples from a cluster of patients with unknown origin pneumonia cases in Wuhan, China. Patients may be asymptomatic or experience mild, moderate or severe symptoms, with or without pneumonia. The severe patients generally require hospitalization on intensive care centers, and will eventually need mechanical invasive ventilation. In this review we approach the latest understanding of literature about the immune response mechanisms against the intracellular pathogen SARS-Cov-2, and review the aspects of innate and adaptive immune responses, and possible evasive mechanisms of these responses by the virus. The understanding of these mechanisms is crucial for the development of therapeutic and immune preventive strategies against the COVID-19, which has configured an important pandemic with high rates of mortality.

Keywords: SARS-CoV-2; COVID-19; Innate Immune response; Adaptive Immune response; Pathogenesis.

 

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Published

2020-08-11

How to Cite

Lima de OLIVEIRA, L. ., Maria Ribeiro de JESUS, A. ., Pacheco de ALMEIDA, R. ., & L. Louzada da SILVA, R. L. L. da S. (2020). Resposta Imune Contra O SARS-CoV-2. Revista Interdisciplinar De Pesquisa E Inovação, 7(2), 82–103. Retrieved from https://ufs.emnuvens.com.br/revipi/article/view/14222

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Artigo